Viral Oncogenesis

You are here

Viral Oncogenesis

Ethel Cesarman, MD, PhD, Principal Investigator

Our laboratory is involved in studying the process of viral oncogenesis in human cancer. We are performing molecular characterization of AIDS-associated lymphomas and Kaposi’s sarcoma, which are frequently associated with infection by EBV (HHV-4) or KSHV (HHV-8), with the goal of identifying molecular targets and developing improved diagnostic and therapeutic strategies.

Active Projects

  • Analysis the viral proteins that provide survival signals to infected tumor cells
  • Develop mouse models of virus-induced malignancy, using xenografts and genetic engineering.
  • Genomics of lymphomas that occur in association with viral infection.
  • Develop methodologies for improved point-of-care diagnosis viral malignancies in poor resource settings.

Active Grants

  • KS-Detect: Kaposi Sarcoma Herpesvirus Research
    PI: Ethel Cesarman, MD,PhD
    Kenneth Horowitz Family Foundation Research Grant
  • KS-Detect: A solar-powered and smartphone integrated instrument for point-of care diagnosis of Kaposi's sarcoma
    PI: Ethel Cesarman, MD,PhD
    National Institutes of Health (NIH) Research Subgrant
  • Modeling KSHV latency in vivo
    PI: Ethel Cesarman, MD,PhD
    National Cancer Institute (NIH)
  • Laboratory Site Agreement
    PI: Ethel Cesarman, MD,PhD
    The AIDS Malignancy Consortium
  • Targeting vFLIP for the Treatment of KSHV-Associated Malignancies
    PI: Ethel Cesarman, MD,PhD
    National Cancer Institute (NIH)
  • Immunology Research Training Program
    PI: Ethel Cesarman, MD,PhD
    National Institute of Allergy and Infectious Diseases (NIH)
  • Solar-Thermal PCR biosensing assay for the diagnosis of Kaposi’s sarcoma in limited resource settings
    PIs: Ethel Cesarman, MD, PhD, David Erickson, PhD
    Weill Cornell CTSC Seed Funds
  • Early Stage Diagnosis of Kaposi's Sarcoma in Limited Resource Settings using KS-Detect
    Co-Investigator: Ethel Cesarman, MD, PhD
    National Cancer Institute (NIH) Cooperative Agreement

Body

Viral Oncogenesis

Ethel Cesarman, MD, PhD, Principal Investigator

Our laboratory is involved in studying the process of viral oncogenesis in human cancer. We are performing molecular characterization of AIDS-associated lymphomas and Kaposi’s sarcoma, which are frequently associated with infection by EBV (HHV-4) or KSHV (HHV-8), with the goal of identifying molecular targets and developing improved diagnostic and therapeutic strategies.

Active Projects

  • Analysis the viral proteins that provide survival signals to infected tumor cells
  • Develop mouse models of virus-induced malignancy, using xenografts and genetic engineering.
  • Genomics of lymphomas that occur in association with viral infection.
  • Develop methodologies for improved point-of-care diagnosis viral malignancies in poor resource settings.

Active Grants

  • KS-Detect: Kaposi Sarcoma Herpesvirus Research
    PI: Ethel Cesarman, MD,PhD
    Kenneth Horowitz Family Foundation Research Grant
  • KS-Detect: A solar-powered and smartphone integrated instrument for point-of care diagnosis of Kaposi's sarcoma
    PI: Ethel Cesarman, MD,PhD
    National Institutes of Health (NIH) Research Subgrant
  • Modeling KSHV latency in vivo
    PI: Ethel Cesarman, MD,PhD
    National Cancer Institute (NIH)
  • Laboratory Site Agreement
    PI: Ethel Cesarman, MD,PhD
    The AIDS Malignancy Consortium
  • Targeting vFLIP for the Treatment of KSHV-Associated Malignancies
    PI: Ethel Cesarman, MD,PhD
    National Cancer Institute (NIH)
  • Immunology Research Training Program
    PI: Ethel Cesarman, MD,PhD
    National Institute of Allergy and Infectious Diseases (NIH)
  • Solar-Thermal PCR biosensing assay for the diagnosis of Kaposi’s sarcoma in limited resource settings
    PIs: Ethel Cesarman, MD, PhD, David Erickson, PhD
    Weill Cornell CTSC Seed Funds
  • Early Stage Diagnosis of Kaposi's Sarcoma in Limited Resource Settings using KS-Detect
    Co-Investigator: Ethel Cesarman, MD, PhD
    National Cancer Institute (NIH) Cooperative Agreement

Selected Publications EXPAND ALL ON THIS PAGE

AMC 048: modified CODOX-M/IVAC-rituximab is safe and effective for HIV-associated Burkitt lymphoma

July 9, 2015
Noy A, Lee JY, Cesarman E, Ambinder R, Baiocchi R, Reid E, Ratner L, Wagner-Johnston N, Kaplan L; AIDS Malignancy Consortium.

AMC 048: modified CODOX-M/IVAC-rituximab is safe and effective for HIV-associated Burkitt lymphoma

Blood. 2015 Jul 9;126(2):160-6.

Noy A, Lee JY, Cesarman E, Ambinder R, Baiocchi R, Reid E, Ratner L, Wagner-Johnston N, Kaplan L; AIDS Malignancy Consortium.

PMID: 25957391; PMCID: PMC4497960

The tumor virus landscape of AIDS-related lymphomas

May 14, 2015
Arvey A, Ojesina AI, Pedamallu CS, Ballon G, Jung J, Duke F, Leoncini L, De Falco G, Bressman E, Tam W, Chadburn A, Meyerson M, Cesarman E.

The tumor virus landscape of AIDS-related lymphomas

Blood. 2015 May 14;125(20):e14-22.

Arvey A, Ojesina AI, Pedamallu CS, Ballon G, Jung J, Duke F, Leoncini L, De Falco G, Bressman E, Tam W, Chadburn A, Meyerson M, Cesarman E.

PMID: 25827832; PMCID: PMC4432014

Flow sorting and exome sequencing reveal the oncogenome of primary Hodgkin and Reed-Sternberg cells

February 12, 2015
Reichel J, Chadburn A, Rubinstein PG, Giulino-Roth L, Tam W, Liu Y, Gaiolla R, Eng K, Brody J, Inghirami G, Carlo-Stella C, Santoro A, Rahal D, Totonchy J, Elemento O, Cesarman E, Roshal M.

Flow sorting and exome sequencing reveal the oncogenome of primary Hodgkin and Reed-Sternberg cells

Blood. 2015 Feb 12;125(7):1061-72.

Reichel J, Chadburn A, Rubinstein PG, Giulino-Roth L, Tam W, Liu Y, Gaiolla R, Eng K, Brody J, Inghirami G, Carlo-Stella C, Santoro A, Rahal D, Totonchy J, Elemento O, Cesarman E, Roshal M.

PMID: 25488972

Systemic expression of Kaposi sarcoma herpesvirus (KSHV) Vflip in endothelial cells leads to a profound proinflammatory phenotype and myeloid lineage remodeling in vivo

January 21, 2015
Ballon G, Akar G, Cesarman E.

Systemic expression of Kaposi sarcoma herpesvirus (KSHV) Vflip in endothelial cells leads to a profound proinflammatory phenotype and myeloid lineage remodeling in vivo

PLoS Pathog. 2015 Jan 21;11(1):e1004581.

Ballon G, Akar G, Cesarman E.

PMID: 25607954; PMCID: PMC4301867

LMP1-deficient Epstein-Barr virus mutant requires T cells for lymphomagenesis

January 1, 2015
Ma SD, Xu X, Plowshay J, Ranheim EA, Burlingham WJ, Jensen JL, Asimakopoulos F, Tang W, Gulley ML, Cesarman E, Gumperz JE, Kenney SC.

LMP1-deficient Epstein-Barr virus mutant requires T cells for lymphomagenesis

J Clin Invest. 2015 Jan;125(1):304-15.

Ma SD, Xu X, Plowshay J, Ranheim EA, Burlingham WJ, Jensen JL, Asimakopoulos F, Tang W, Gulley ML, Cesarman E, Gumperz JE, Kenney SC.

PMID: 25485679; PMCID: PMC4382240

KSHV viral cyclin interferes with T-cell development and induces lymphoma through Cdk6 and Notch activation in vivo

December 1, 2014
Pekkonen P, Järviluoma A, Zinovkina N, Cvrljevic A, Prakash S, Westermarck J, Evan GI, Cesarman E, Verschuren EW, Ojala PM.

KSHV viral cyclin interferes with T-cell development and induces lymphoma through Cdk6 and Notch activation in vivo

Cell Cycle. 2014;13(23):3670-84.

Pekkonen P, Järviluoma A, Zinovkina N, Cvrljevic A, Prakash S, Westermarck J, Evan GI, Cesarman E, Verschuren EW, Ojala PM.

PMID: 25483078

FOXO1 repression contributes to block of plasma cell differentiation in classical Hodgkin lymphoma.

November 13, 2014
Vogel MJ, Xie L, Guan H, Tooze RM, Maier T, Kostezka U, Maier HJ, Holzmann K, Chan FC, Steidl C, Reichel JB, Weitzer CD, Gehringer F, Kick AB, Cesarman E, Roshal M, Gascoyne RD, Möller P, Wirth T, Ushmorov A.

FOXO1 repression contributes to block of plasma cell differentiation in classical Hodgkin lymphoma.

Blood. 2014 Nov 13;124(20):3118-29.

Vogel MJ, Xie L, Guan H, Tooze RM, Maier T, Kostezka U, Maier HJ, Holzmann K, Chan FC, Steidl C, Reichel JB, Weitzer CD, Gehringer F, Kick AB, Cesarman E, Roshal M, Gascoyne RD, Möller P, Wirth T, Ushmorov A.

PMID: 25232062.

Detection of Kaposi's sarcoma associated herpesvirus nucleic acids using a smartphone accessory.

October 7, 2014
Mancuso M, Cesarman E, Erickson D.

Detection of Kaposi's sarcoma associated herpesvirus nucleic acids using a smartphone accessory.

Lab Chip. 2014 Oct 7;14(19):3809-16.

Mancuso M, Cesarman E, Erickson D.

PMID: 25117534.

How do viruses trick B cells into becoming lymphomas?

July 1, 2014
Cesarman E.

How do viruses trick B cells into becoming lymphomas?

Curr Opin Hematol. 2014 Jul;21(4):358-68.

Cesarman E.

PMID: 24886824; PMCID: PMC4126608

Solar thermal polymerase chain reaction for smartphone-assisted molecular diagnostics.

February 20, 2014
Jiang L, Mancuso M, Lu Z, Akar G, Cesarman E, Erickson D.

Solar thermal polymerase chain reaction for smartphone-assisted molecular diagnostics.

Sci Rep. 2014 Feb 20;4:4137. 

Jiang L, Mancuso M, Lu Z, Akar G, Cesarman E, Erickson D.

PMID: 24553130; PMCID: PMC3929917.

Gammaherpesviruses and lymphoproliferative disorders.

January 1, 2014
Cesarman E.

Gammaherpesviruses and lymphoproliferative disorders.

Annu Rev Pathol. 2014;9:349-72.

Cesarman E.

PMID: 24111911.

Targeting the Hsp90-associated viral oncoproteome in gammaherpesvirus-associated malignancies.

October 17, 2013
Nayar U, Lu P, Goldstein RL, Vider J, Ballon G, Rodina A, Taldone T, Erdjument-Bromage H, Chomet M, Blasberg R, Melnick A, Cerchietti L, Chiosis G, Wang YL, Cesarman E.

Targeting the Hsp90-associated viral oncoproteome in gammaherpesvirus-associated malignancies.

Blood. 2013 Oct 17;122(16):2837-47. 

Nayar U, Lu P, Goldstein RL, Vider J, Ballon G, Rodina A, Taldone T, Erdjument-Bromage H, Chomet M, Blasberg R, Melnick A, Cerchietti L, Chiosis G, Wang YL, Cesarman E. 

PMID: 23943653; PMCID: PMC3798998.

Pathology of lymphoma in HIV.

September 25, 2013
Ethel Cesarman, MD

Pathology of lymphoma in HIV.

Curr Opin Oncol. 2013 Sep;25(5):487-94. 

Cesarman E.

PMID: 23942293

Inherited human OX40 deficiency underlying classic Kaposi sarcoma of childhood.

August 26, 2013
Ethel Cesarman, MD

Inherited human OX40 deficiency underlying classic Kaposi sarcoma of childhood.

J Exp Med. 2013 Aug 26;210(9):1743-59. 

Byun M, Ma CS, Akçay A, Pedergnana V, Palendira U, Myoung J, Avery DT, Liu Y, Abhyankar A, Lorenzo L, Schmidt M, Lim HK, Cassar O, Migaud M, Rozenberg F, Canpolat N, Aydogan G, Fleckenstein B, Bustamante J, Picard C, Gessain A, Jouanguy E, Cesarman E, Olivier M, Gros P, Abel L, Croft M, Tangye SG, Casanova JL.

PMID: 23897980

Multiplexed colorimetric detection of Kaposi's sarcoma associated herpesvirus and Bartonella DNA using gold and silver nanoparticles.

February 21, 2013
Mancuso M, Jiang L, Cesarman E, Erickson D.

Multiplexed colorimetric detection of Kaposi's sarcoma associated herpesvirus and Bartonella DNA using gold and silver nanoparticles.

Nanoscale. 2013 Feb 21;5(4):1678-86.

Mancuso M, Jiang L, Cesarman E, Erickson D.

PMID: 23340972

Pegylated liposomal doxorubicin, rituximab, cyclophosphamide, vincristine, and prednisone in AIDS-related lymphoma: AIDS Malignancy Consortium Study 047.

January 1, 2013
Levine AM, Noy A, Lee JY, Tam W, Ramos JC, Henry DH, Parekh S, Reid EG, Mitsuyasu R, Cooley T, Dezube BJ, Ratner L, Cesarman E, Tulpule A.

Pegylated liposomal doxorubicin, rituximab, cyclophosphamide, vincristine, and prednisone in AIDS-related lymphoma: AIDS Malignancy Consortium Study 047.

J Clin Oncol. 2013 Jan 1;31(1):58-64.

Levine AM, Noy A, Lee JY, Tam W, Ramos JC, Henry DH, Parekh S, Reid EG, Mitsuyasu R, Cooley T, Dezube BJ, Ratner L, Cesarman E, Tulpule A.

PMID: 23169503

Targeted genomic sequencing of pediatric Burkitt lymphoma identifies recurrent alterations in antiapoptotic and chromatin-remodeling genes.

December 20, 2012
Giulino-Roth L, Wang K, MacDonald TY, Mathew S, Tam Y, Cronin MT, Palmer G, Lucena-Silva N, Pedrosa F, Pedrosa M, Teruya-Feldstein J, Bhagat G, Alobeid B, Leoncini L, Bellan C, Rogena E, Pinkney KA, Rubin MA, Ribeiro RC, Yelensky R, Tam W, Stephens PJ, Ce

Targeted genomic sequencing of pediatric Burkitt lymphoma identifies recurrent alterations in antiapoptotic and chromatin-remodeling genes.

Blood. 2012 Dec 20;120(26):5181-4.

Giulino-Roth L, Wang K, MacDonald TY, Mathew S, Tam Y, Cronin MT, Palmer G, Lucena-Silva N, Pedrosa F, Pedrosa M, Teruya-Feldstein J, Bhagat G, Alobeid B, Leoncini L, Bellan C, Rogena E, Pinkney KA, Rubin MA, Ribeiro RC, Yelensky R, Tam W, Stephens PJ, Cesarman E.

PMID: 23091298

A20 (TNFAIP3) genetic alterations in EBV-associated AIDS-related lymphoma.

May 5, 2011
Ballon G

A20 (TNFAIP3) genetic alterations in EBV-associated AIDS-related lymphoma.

Blood. 2011 May 5;117(18):4852-4.

Giulino L, Mathew S, Ballon G, Chadburn A, Barouk S, Antonicelli G, Leoncini L, Liu YF, Gogineni S, Tam W, Cesarman E.

PMID: 21406721

Pilot study of oral valganciclovir therapy in patients with classic Kaposi sarcoma.

April 15, 2011
Ethel Cesarman, MD

Pilot study of oral valganciclovir therapy in patients with classic Kaposi sarcoma.

J Infect Dis. 2011 Apr 15;203(8):1082-6.

Krown SE, Dittmer DP, Cesarman E.

PMID: 21450998

Kaposi sarcoma herpesvirus (KSHV) vFLIP oncoprotein induces B cell transdifferentiation and tumorigenesis in mice.

March 1, 2011
Ballon G, Chen K, Perez R, Tam W, Cesarman E.

Kaposi sarcoma herpesvirus (KSHV) vFLIP oncoprotein induces B cell transdifferentiation and tumorigenesis in mice.

J Clin Invest. 2011 Mar;121(3):1141-53.

Ballon G, Chen K, Perez R, Tam W, Cesarman E.

PMID: 21339646; PMCID: PMC3049379

Kaposi's sarcoma and its associated herpesvirus

October 1, 2010
Mesri EA, Cesarman E, Boshoff C.

Kaposi's sarcoma and its associated herpesvirus

Nat Rev Cancer. 2010 Oct;10(10):707-19.

Mesri EA, Cesarman E, Boshoff C.

PMID: 20865011

Immunophenotypic analysis of AIDS-related diffuse large B-cell lymphoma and clinical implications in patients from AIDS Malignancies Consortium clinical trials 010 and 034.

October 20, 2009
Chadburn A, Chiu A, Lee JY, Chen X, Hyjek E, Banham AH, Noy A, Kaplan LD, Sparano JA, Bhatia K, Cesarman E.

Immunophenotypic analysis of AIDS-related diffuse large B-cell lymphoma and clinical implications in patients from AIDS Malignancies Consortium clinical trials 010 and 034.

J Clin Oncol. 2009 Oct 20;27(30):5039-48. 

Chadburn A, Chiu A, Lee JY, Chen X, Hyjek E, Banham AH, Noy A, Kaplan LD, Sparano JA, Bhatia K, Cesarman E.

PMID: 19752343; PMCID: PMC2799056

KSHV LANA inhibits TGF-beta signaling through epigenetic silencing of the TGF-beta type II receptor

May 1, 2008
Di Bartolo DL, Cannon M, Liu YF, Renne R, Chadburn A, Boshoff C, Cesarman E.

KSHV LANA inhibits TGF-beta signaling through epigenetic silencing of the TGF-beta type II receptor

Blood. 2008 May 1;111(9):4731-40.

Di Bartolo DL, Cannon M, Liu YF, Renne R, Chadburn A, Boshoff C, Cesarman E.

PMID: 18199825; PMCID: PMC2343603

EBV LMP2A mediated LMP1 signaling and survival of lymphoma cells through TRAF2 regulation

April 1, 2008
Cesarman E

EBV LMP2A mediated LMP1 signaling and survival of lymphoma cells through TRAF2 regulation

Blood. 111:3813-3820, 2008.

Guasparri I, Bubman D, Cesarman E

PMID: 18230756

KSHV vFLIP is essential for the survival of infected lymphoma cells

April 5, 2004
Cesarman E

KSHV vFLIP is essential for the survival of infected lymphoma cells

J. Exp. Med. 199:993-1003, 2004.

Guasparri I, Keller SA, Cesarman E

PMID: 15067035

Kaposi's sarcoma-associated herpesvirus--the high cost of viral survival

January 1, 2003
Cesarman E

Kaposi's sarcoma-associated herpesvirus--the high cost of viral survival

N Engl J Med. 349:1107-1109,2003.

Cesarman E.

PMID: 13679522

Transformation of primary human endothelial cells by Kaposi's sarcoma-associated herpesvirus.

August 6, 1998
Flore O, Rafii S, Ely J, O'Leary JO, Hyjek EM, Cesarman E

Transformation of primary human endothelial cells by Kaposi's sarcoma-associated herpesvirus.

Nature. 1998 Aug 6;394(6693):588-92.

Flore O, Rafii S, Ely S, O'Leary JJ, Hyjek EM, Cesarman E.

PMID: 9707121

Human herpesvirus KSHV encodes a constitutively active G-protein-coupled receptor linked to cell proliferation

January 23, 1997
Cesarman E

Human herpesvirus KSHV encodes a constitutively active G-protein-coupled receptor linked to cell proliferation

Nature. 1997 Jan 23;385(6614):347-50. 

Arvanitakis L, Geras-Raaka E, Varma A, Gershengorn MC, Cesarman E. 

PMID: 9002520.

Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas

May 4, 1995
Cesarman E, Chang Y, Moore PS, Said JW, Knowles DM

Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas

N Engl J Med. 1995 May 4;332(18):1186-91.

Cesarman E, Chang Y, Moore PS, Said JW, Knowles DM.

PMID: 7700311

Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma.

December 16, 1994
Chang Y, Cesarman E, Pessin M, Lee F, Culpepper J, Knowles DM, Moore PS

Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma.

Science. 1994 Dec 16;266(5192):1865-9.

Chang Y, Cesarman E, Pessin MS, Lee F, Culpepper J, Knowles DM, Moore PS.

PMID: 7997879

Research faculty

General Contact

Ethel Cesarman, MD, Ph.D.
Professor of Pathology and Laboratory Medicine
Weill Cornell Medical College
1300 York Avenue, C-410B
New York, NY 10065
Tel: 212-746-8838
Fax: 212-746-4416
ecesarm@med.cornell.edu

BACK TO TOP