Vascular Biology

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Center for Vascular Biology

Dr. Di Lorenzo’s laboratory is interested in two major area of research: one is to define the molecular mechanisms by which endothelial nitric oxide synthase (eNOS)-derived NO controls the endothelial barrier functions to the passage of plasma molecules and inflammatory cells.Another area of research focuses on the role of Nogo-B, belonging to the Reticulon-4 family of proteins expressed in the ER, in vascular function regulation and in cardiac hypertrophy development.

Active Projects

  • To study the role of eNOS in vascular permeability and inflammatory cell recruitment to the site of inflammation.
  • To investigate the role of Nogo-B in vascular function and cardiac hypertrophy.

Active Grants

  • Endothelial sphingolipid synthesis and tissue inflammatory response
    PI: Dr. Annarita Di Lorenzo, PhD
    National Institutes of Health (NIH)
  • Endothelial-derived Sphingolipids in Coronary Atherosclerosis
    PI: Annarita Di Lorenzo, PhD
    Harold S. Geneen Charitable Trust Awards Program for Coronary Heart Disease Research
  • Role of Nitric Oxide (NO) in Regulating VE-Cadherin Biological Functions
    PI: Annarita Di Lorenzo, PhD
    American Heart Association (AHA)

Center for Vascular Biology

Dr. Di Lorenzo’s laboratory is interested in two major area of research: one is to define the molecular mechanisms by which endothelial nitric oxide synthase (eNOS)-derived NO controls the endothelial barrier functions to the passage of plasma molecules and inflammatory cells.Another area of research focuses on the role of Nogo-B, belonging to the Reticulon-4 family of proteins expressed in the ER, in vascular function regulation and in cardiac hypertrophy development.

Active Projects

  • To study the role of eNOS in vascular permeability and inflammatory cell recruitment to the site of inflammation.
  • To investigate the role of Nogo-B in vascular function and cardiac hypertrophy.

Active Grants

  • Endothelial sphingolipid synthesis and tissue inflammatory response
    PI: Dr. Annarita Di Lorenzo, PhD
    National Institutes of Health (NIH)
  • Endothelial-derived Sphingolipids in Coronary Atherosclerosis
    PI: Annarita Di Lorenzo, PhD
    Harold S. Geneen Charitable Trust Awards Program for Coronary Heart Disease Research
  • Role of Nitric Oxide (NO) in Regulating VE-Cadherin Biological Functions
    PI: Annarita Di Lorenzo, PhD
    American Heart Association (AHA)

Selected Publications EXPAND ALL ON THIS PAGE

HIF-1α in vascular smooth muscle regulates blood pressure homeostasis through a PPARγ-angiotensin I receptor type 1 axis

August 19, 2013
Huang Y*, Di Lorenzo A. *, Jiang W., Cantalupo A., Sessa W. C., Giordano F.J

HIF-1α in vascular smooth muscle regulates blood pressure homeostasis through a PPARγ-angiotensin I receptor type 1 axis

Hypertension. 2013 Sep;62(3):634-40.

Huang Y, Di Lorenzo A, Jiang W, Cantalupo A, Sessa WC, Giordano FJ.

PMID: 23918749

Normal glucose uptake in the brain and heart requires an endothelial cell-specific HIF-1α-dependent function

January 1, 2012
Huang Y., Lei L., Liu D., Jovin I., Russell R., Johnson R.S., Di Lorenzo A., Giordano F.J

Normal glucose uptake in the brain and heart requires an endothelial cell-specific HIF-1α-dependent function

Proc Natl Acad Sci U S A. 2012 Oct 23;109(43):17478-83.

Huang Y, Lei L, Liu D, Jovin I, Russell R, Johnson RS, Di Lorenzo A, Giordano FJ.

PMID: 23047702; PMCID: PMC3491491

Smooth muscle miRNAs are critical for post-natal regulation of blood pressure and vascular function.

April 22, 2011
Annarita DiLorenzo, PhD

Smooth muscle miRNAs are critical for post-natal regulation of blood pressure and vascular function.

PLoS One. 2011 Apr 22;6(4):e18869. 

Albinsson S, Skoura A, Yu J, DiLorenzo A, Fernández-Hernando C, Offermanns S, Miano JM, Sessa WC.

PMID: 21526127

Endothelial Reticulon-4B (Nogo-B) regulates ICAM-1-mediated leukocyte transmigration and acute inflammation

January 1, 2011
Di Lorenzo A., Manes T.D., Wright P.L. and Sessa W.C

Endothelial Reticulon-4B (Nogo-B) regulates ICAM-1-mediated leukocyte transmigration and acute inflammation

Blood. 2011 Feb 17;117(7):2284-95.

Di Lorenzo A, Manes TD, Davalos A, Wright PL, Sessa WC.

PMID: 21183689; PMCID: PMC3062334

CCM3 signaling through sterile 20-like kinases plays an essential role during zebrafish cardiovascular development and cerebral cavernous malformations

January 1, 2010
Zheng X., Xu C., Di Lorenzo A., Kleaveland B., Zou Z., Seiler C., Chen M., Cheng L., Xiao J., He J., Pack M.A., Sessa W.C., Kahn M.L

CCM3 signaling through sterile 20-like kinases plays an essential role during zebrafish cardiovascular development and cerebral cavernous malformations

J Clin Invest. 2010 Aug;120(8):2795-804.

Zheng X, Xu C, Di Lorenzo A, Kleaveland B, Zou Z, Seiler C, Chen M, Cheng L, Xiao J, He J, Pack MA, Sessa WC, Kahn ML.

PMID: 20592472; PMCID: PMC2912181

Telmisartan regresses left ventricular hypertrophy in caveolin-1-deficient mice

January 1, 2010
Di Lorenzo A., Kreiger M.H., Teutsch C., Kauser K. and Sessa W.C

Telmisartan regresses left ventricular hypertrophy in caveolin-1-deficient mice

Lab Invest. 2010 Nov;90(11):1573-81.

Krieger MH, Di Lorenzo A, Teutsch C, Kauser K, Sessa WC.

PMID: 20585312; PMCID: PMC3248785

Sin1-mTORC2 suppresses rag and il7r gene expression through Akt2 in B cells

January 1, 2010
Lazorchak A.D., Liu D., Facchinetti V., Di Lorenzo A., Sessa W.C., Schatz D.G. and Su B

Sin1-mTORC2 suppresses rag and il7r gene expression through Akt2 in B cells

Mol Cell. 2010 Aug 13;39(3):433-43.

Lazorchak AS, Liu D, Facchinetti V, Di Lorenzo A, Sessa WC, Schatz DG, Su B.

PMID: 20705244; PMCID: PMC2957800

Hydrogen sulphide is involved in testosterone vascular effect

August 1, 2009
Bucci M., Mirone V., Di Lorenzo A., Vellecco V., Roviezzo F., Brancaleone V., Ciro I., Cirino G

Hydrogen sulphide is involved in testosterone vascular effect

Eur Urol. 2009 Aug;56(2):378-83.

Bucci M, Mirone V, Di Lorenzo A, Vellecco V, Roviezzo F, Brancaleone V, Ciro I, Cirino G.

PMID: 18511180

The Akt1-eNOS axis illustrates the specificity of kinase-substrate relationships in vivo

January 1, 2009
Schleicher M., Yu J., Murata T., Derakhshan B., Atochin D., Qian L., Kashiwagi S., Di Lorenzo A., Harrison K.D., Huang P.L., and Sessa W.C

The Akt1-eNOS axis illustrates the specificity of kinase-substrate relationships in vivo

Sci Signal. 2009 Aug 4;2(82):ra41.

Schleicher M, Yu J, Murata T, Derakhshan B, Atochin D, Qian L, Kashiwagi S, Di Lorenzo A, Harrison KD, Huang PL, Sessa WC.

PMID: 19654415

Akt1 is critical for acute inflammation and histamine-mediated vascular leakage

January 1, 2009
Di Lorenzo A., Fernandez-Hernando C, Cirino G. and Sessa W.C

Akt1 is critical for acute inflammation and histamine-mediated vascular leakage

Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14552-7.

Di Lorenzo A, Fernández-Hernando C, Cirino G, Sessa WC.

PMID: 19622728; PMCID: PMC2732859

Absence of Akt1 reduces vascular smooth muscle cell migration and survival and induces features of plaque vulnerability and cardiac dysfunction during atherosclerosis

January 1, 2009
Fernandez-Hernando C, Jozsef L, Jenkins D., Di Lorenzo A. and Sessa W.C.

Absence of Akt1 reduces vascular smooth muscle cell migration and survival and induces features of plaque vulnerability and cardiac dysfunction during atherosclerosis

Arterioscler Thromb Vasc Biol. 2009 Dec;29(12):2033-40.

Fernández-Hernando C, József L, Jenkins D, Di Lorenzo A, Sessa WC.

PMID: 19762778; PMCID: PMC2796372

Reticulon 4B (Nogo-B) is necessary for macrophage infiltration and tissue repair

January 1, 2009
Yu J., Fernandez-Hernando C., Suarez Y., Schleicher M., Hao Z., Wright P., Di Lorenzo A., Kyriakides T. and Sessa W.C

Reticulon 4B (Nogo-B) is necessary for macrophage infiltration and tissue repair

Proc Natl Acad Sci U S A. 2009 Oct 13;106(41):17511-6.

Yu J, Fernández-Hernando C, Suarez Y, Schleicher M, Hao Z, Wright PL, DiLorenzo A, Kyriakides TR, Sessa WC.

PMID: 19805174; PMCID: PMC2762666

Sphingosine-1-phosphate/sphingosine kinase pathway is involved in mouse airway hyperresponsiveness

June 1, 2007
Di Lorenzo A., Roviezzo F., Bucci M., Brancaleone V., Vellecco V., De Nardo M., Orlotti D., De Palma R., Rossi F., D'Agostino B., Cirino G

Sphingosine-1-phosphate/sphingosine kinase pathway is involved in mouse airway hyperresponsiveness

Am J Respir Cell Mol Biol. 2007 Jun;36(6):757-62. 

Roviezzo F, Di Lorenzo A, Bucci M, Brancaleone V, Vellecco V, De Nardo M, Orlotti D, De Palma R, Rossi F, D'Agostino B, Cirino G.

PMID: 17322125.

General Contact

Mario A. Castro Martinez, Executive Assistant to Dr. Hla
Administrative Specialist
Pathology and Laboratory Medicine
Weill Cornell Medical College
1300 York Avenue, A-610
New York, NY 10065
Tel: 212-746-9844
Fax: 212-746-8789
mcm2010@med.cornell.edu

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