Oncogenic Transcription Factors in Prostate Cancer

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Oncogenic Transcription Factors in Prostate Cancer

David Rickman, PhD, Principal Investigator

The Oncogenic Transcription Factors in Prostate Cancer laboratory is focused on elucidating the role of oncogenic transcription factors (e.g. ETS family members and N-Myc) in coordinating gene regulation, chromatin 3D architecture and response to chemotherapy in the context of prostate adenocarcinoma and neuroendocrine prostate cancer.

Active Projects

  • The role of ERG in mediating taxane resistance.
  • The role of N-Myc in driving the neuroendocrine prostate cancer phenotype.
  • Development of in vitro and in vivo model systems of oncogenic transcription factor over-expression and other genomic alterations in prostate cancer.

Active Grants

  • Janssen-Challenge Award
    Prostate Cancer Foundation
    “Targeting and mechanistic insights underlying N-Myc driven Neuroendocrine Prostate Cancer”
    The aim of this study is to characterize the driving role of N-Myc and AURKA in neuroendocrine prostate cancer with the ultimate goal of more effectively targeting this tumor subclass by disrupting this complex.
    Role: PI
  • 1R01CA179100-01A1
    NIH-National Cancer Institute
    “Mechanistic Insights Underlying ERG-induced Taxane Resistance in Castration-Resistant Prostate Cancer”
    The aim of this study is to characterize the mechanism underlying ERG-induced taxane resistance in castrate resistant prostate cancer.
    Role: PI

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Oncogenic Transcription Factors in Prostate Cancer

David Rickman, PhD, Principal Investigator

The Oncogenic Transcription Factors in Prostate Cancer laboratory is focused on elucidating the role of oncogenic transcription factors (e.g. ETS family members and N-Myc) in coordinating gene regulation, chromatin 3D architecture and response to chemotherapy in the context of prostate adenocarcinoma and neuroendocrine prostate cancer.

Active Projects

  • The role of ERG in mediating taxane resistance.
  • The role of N-Myc in driving the neuroendocrine prostate cancer phenotype.
  • Development of in vitro and in vivo model systems of oncogenic transcription factor over-expression and other genomic alterations in prostate cancer.

Active Grants

  • Janssen-Challenge Award
    Prostate Cancer Foundation
    “Targeting and mechanistic insights underlying N-Myc driven Neuroendocrine Prostate Cancer”
    The aim of this study is to characterize the driving role of N-Myc and AURKA in neuroendocrine prostate cancer with the ultimate goal of more effectively targeting this tumor subclass by disrupting this complex.
    Role: PI
  • 1R01CA179100-01A1
    NIH-National Cancer Institute
    “Mechanistic Insights Underlying ERG-induced Taxane Resistance in Castration-Resistant Prostate Cancer”
    The aim of this study is to characterize the mechanism underlying ERG-induced taxane resistance in castrate resistant prostate cancer.
    Role: PI

Selected Publications EXPAND ALL ON THIS PAGE

ERG induces taxane resistance in castration-resistant prostate cancer.

November 25, 2014
Galletti G, Matov A, Beltran H, Fontugne J, Miguel Mosquera J, Cheung C, MacDonald TY, Sung M, O'Toole S, Kench JG, Suk Chae S, Kimovski D, Tagawa ST, Nanus DM, Rubin MA, Horvath LG, Giannakakou P, Rickman DS.

ERG induces taxane resistance in castration-resistant prostate cancer.

Nat Commun. 2014 Nov 25;5:5548. 

Galletti G, Matov A, Beltran H, Fontugne J, Miguel Mosquera J, Cheung C, MacDonald TY, Sung M, O'Toole S, Kench JG, Suk Chae S, Kimovski D, Tagawa ST, Nanus DM, Rubin MA, Horvath LG, Giannakakou P, Rickman DS. 

PubMed PMID: 25420520; PMCID: PMC4244604

Aggressive variants of castration-resistant prostate cancer

June 1, 2014
Beltran H, Tomlins S, Aparicio A, Arora V, Rickman D, Ayala G, Huang J, True L, Gleave ME, Soule H, Logothetis C, Rubin MA.

Aggressive variants of castration-resistant prostate cancer

Clin Cancer Res. 2014 Jun 1;20(11):2846-50.

Beltran H, Tomlins S, Aparicio A, Arora V, Rickman D, Ayala G, Huang J, True L, Gleave ME, Soule H, Logothetis C, Rubin MA.

PMID: 24727321; PMCID: PMC4040316

Combining urinary detection of TMPRSS2:ERG and PCA3 with serum PSA to predict diagnosis of prostate cancer.

July 1, 2013
Salami SS, Schmidt F, Laxman B, Regan MM, Rickman DS, Scherr D, Bueti G, Siddiqui J, Tomlins SA, Wei JT, Chinnaiyan AM, Rubin MA, Sanda MG.

Combining urinary detection of TMPRSS2:ERG and PCA3 with serum PSA to predict diagnosis of prostate cancer.

Urol Oncol. 2013 Jul;31(5):566-71. 

Salami SS, Schmidt F, Laxman B, Regan MM, Rickman DS, Scherr D, Bueti G, Siddiqui J, Tomlins SA, Wei JT, Chinnaiyan AM, Rubin MA, Sanda MG.

PMID: 21600800

Oncogenic transcription factors as master regulators of chromatin topology: a new role for ERG in prostate cancer

September 15, 2012
Elemento O, Rubin MA, Rickman DS.

Oncogenic transcription factors as master regulators of chromatin topology: a new role for ERG in prostate cancer

Cell Cycle. 2012 Sep 15;11(18):3380-3.

Elemento O, Rubin MA, Rickman DS.  

PMID: 22918253; PMCID: PMC3466547

Oncogene-mediated alterations in chromatin conformation

June 5, 2012
Rickman DS, Soong TD, Moss B, Mosquera JM, Dlabal J, Terry S, MacDonald TY, Tripodi J, Bunting K, Najfeld V, Demichelis F, Melnick AM, Elemento O, Rubin MA.

Oncogene-mediated alterations in chromatin conformation

Proc Natl Acad Sci U S A. 2012 Jun 5;109(23):9083-8.

Rickman DS, Soong TD, Moss B, Mosquera JM, Dlabal J, Terry S, MacDonald TY, Tripodi J, Bunting K, Najfeld V, Demichelis F, Melnick AM, Elemento O, Rubin MA.

PMID: 22615383; PMCID: PMC3384175

Discovery of non-ETS gene fusions in human prostate cancer using next-generation RNA sequencing

January 1, 2011
Pflueger D, Terry S, Sboner A, Habegger L, Esgueva R, Lin PC, Svensson MA, Kitabayashi N, Moss BJ, MacDonald TY, Cao X, Barrette T, Tewari AK, Chee MS, Chinnaiyan AM, Rickman DS, Demichelis F, Gerstein MB, Rubin MA.

Discovery of non-ETS gene fusions in human prostate cancer using next-generation RNA sequencing

Genome Res. 2011 Jan;21(1):56-67.

Pflueger D, Terry S, Sboner A, Habegger L, Esgueva R, Lin PC, Svensson MA, Kitabayashi N, Moss BJ, MacDonald TY, Cao X, Barrette T, Tewari AK, Chee MS, Chinnaiyan AM, Rickman DS, Demichelis F, Gerstein MB, Rubin MA.

PMID: 21036922; PMCID: PMC3012926

ERG cooperates with androgen receptor in regulating trefoil factor 3 in prostate cancer disease progression

December 1, 2010
Rickman DS, Chen YB, Banerjee S, Pan Y, Yu J, Vuong T, Perner S, Lafargue CJ, Mertz KD, Setlur SR, Sircar K, Chinnaiyan AM, Bismar TA, Rubin MA, Demichelis F.

ERG cooperates with androgen receptor in regulating trefoil factor 3 in prostate cancer disease progression

Neoplasia. 2010 Dec;12(12):1031-40.

Rickman DS, Chen YB, Banerjee S, Pan Y, Yu J, Vuong T, Perner S, Lafargue CJ, Mertz KD, Setlur SR, Sircar K, Chinnaiyan AM, Bismar TA, Rubin MA, Demichelis F.

PMID: 21170267; PMCID: PMC3003138

ERG rearrangement metastasis patterns in locally advanced prostate cancer

April 1, 2010
Perner S, Svensson MA, Hossain RR, Day JR, Groskopf J, Slaughter RC, Jarleborn AR, Hofer MD, Kuefer R, Demichelis F, Rickman DS, Rubin MA.

ERG rearrangement metastasis patterns in locally advanced prostate cancer

Urology. 2010 Apr;75(4):762-7.

Perner S, Svensson MA, Hossain RR, Day JR, Groskopf J, Slaughter RC, Jarleborn AR, Hofer MD, Kuefer R, Demichelis F, Rickman DS, Rubin MA.

PMID: 20018353; PMCID: PMC2850965

WNT/beta-catenin pathway activation in Wilms tumors: a unifying mechanism with multiple entries?

September 1, 2009
Corbin M, de Reyniès A, Rickman DS, Berrebi D, Boccon-Gibod L, Cohen-Gogo S, Fabre M, Jaubert F, Faussillon M, Yilmaz F, Sarnacki S, Landman-Parker J, Patte C, Schleiermacher G, Antignac C, Jeanpierre C.

WNT/beta-catenin pathway activation in Wilms tumors: a unifying mechanism with multiple entries?

Genes Chromosomes Cancer. 2009 Sep;48(9):816-27.

Corbin M, de Reyniès A, Rickman DS, Berrebi D, Boccon-Gibod L, Cohen-Gogo S, Fabre M, Jaubert F, Faussillon M, Yilmaz F, Sarnacki S, Landman-Parker J, Patte C, Schleiermacher G, Antignac C, Jeanpierre C.

PMID: 19530245

N-myc downstream regulated gene 1 (NDRG1) is fused to ERG in prostate cancer.

August 1, 2009
Pflueger D, Rickman DS, Sboner A, Perner S, LaFargue CJ, Svensson MA, Moss BJ, Kitabayashi N, Pan Y, de la Taille A, Kuefer R, Tewari AK, Demichelis F, Chee MS, Gerstein MB, Rubin MA.

N-myc downstream regulated gene 1 (NDRG1) is fused to ERG in prostate cancer.

Neoplasia. 2009 Aug;11(8):804-11.

Pflueger D, Rickman DS, Sboner A, Perner S, LaFargue CJ, Svensson MA, Moss BJ, Kitabayashi N, Pan Y, de la Taille A, Kuefer R, Tewari AK, Demichelis F, Chee MS, Gerstein MB, Rubin MA.

PMID: 19649210; PMCID: PMC2713587

Distinct genomic aberrations associated with ERG rearranged prostate cancer.

April 1, 2009
Demichelis F, Setlur SR, Beroukhim R, Perner S, Korbel JO, Lafargue CJ, Pflueger D, Pina C, Hofer MD, Sboner A, Svensson MA, Rickman DS, Urban A, Snyder M, Meyerson M, Lee C, Gerstein MB, Kuefer R, Rubin MA.

Distinct genomic aberrations associated with ERG rearranged prostate cancer.

Genes Chromosomes Cancer. 2009 Apr;48(4):366-80.

Demichelis F, Setlur SR, Beroukhim R, Perner S, Korbel JO, Lafargue CJ, Pflueger D, Pina C, Hofer MD, Sboner A, Svensson MA, Rickman DS, Urban A, Snyder M, Meyerson M, Lee C, Gerstein MB, Kuefer R, Rubin MA.

PMID: 19156837; PMCID: PMC2674964

SLC45A3-ELK4 is a novel and frequent erythroblast transformation-specific fusion transcript in prostate cancer.

April 1, 2009
Rickman DS, Pflueger D, Moss B, VanDoren VE, Chen CX, de la Taille A, Kuefer R, Tewari AK, Setlur SR, Demichelis F, Rubin MA.

SLC45A3-ELK4 is a novel and frequent erythroblast transformation-specific fusion transcript in prostate cancer.

Cancer Res. 2009 Apr 1;69(7):2734-8.

Rickman DS, Pflueger D, Moss B, VanDoren VE, Chen CX, de la Taille A, Kuefer R, Tewari AK, Setlur SR, Demichelis F, Rubin MA.

PMID: 19293179; PMCID: PMC4063441

Gene expression profiling reveals a new classification of adrenocortical tumors and identifies molecular predictors of malignancy and survival

March 1, 2009
de Reyniès A, Assié G, Rickman DS, Tissier F, Groussin L, René-Corail F, Dousset B, Bertagna X, Clauser E, Bertherat J.

Gene expression profiling reveals a new classification of adrenocortical tumors and identifies molecular predictors of malignancy and survival

J Clin Oncol. 2009 Mar 1;27(7):1108-15.

de Reyniès A, Assié G, Rickman DS, Tissier F, Groussin L, René-Corail F, Dousset B, Bertagna X, Clauser E, Bertherat J.

PMID: 19139432

Hepatic stem-like phenotype and interplay of Wnt/beta-catenin and Myc signaling in aggressive childhood liver cancer

December 9, 2008
Cairo S, Armengol C, De Reyniès A, Wei Y, Thomas E, Renard CA, Goga A, Balakrishnan A, Semeraro M, Gresh L, Pontoglio M, Strick-Marchand H, Levillayer F, Nouet Y, Rickman D, Gauthier F, Branchereau S, Brugières L, Laithier V, Bouvier R, Boman F, Basso G,

Hepatic stem-like phenotype and interplay of Wnt/beta-catenin and Myc signaling in aggressive childhood liver cancer

Cancer Cell. 2008 Dec 9;14(6):471-84.

Cairo S, Armengol C, De Reyniès A, Wei Y, Thomas E, Renard CA, Goga A, Balakrishnan A, Semeraro M, Gresh L, Pontoglio M, Strick-Marchand H, Levillayer F, Nouet Y, Rickman D, Gauthier F, Branchereau S, Brugières L, Laithier V, Bouvier R, Boman F, Basso G, Michiels JF, Hofman P, Arbez-Gindre F, Jouan H, Rousselet-Chapeau MC, Berrebi D, Marcellin L, Plenat F, Zachar D, Joubert M, Selves J, Pasquier D, Bioulac-Sage P, Grotzer M, Childs M, Fabre M, Buendia MA.

PMID: 19061838

Prediction of future metastasis and molecular characterization of head and neck squamous-cell carcinoma based on transcriptome and genome analysis by microarrays

November 20, 2008
Rickman DS, Millon R, De Reynies A, Thomas E, Wasylyk C, Muller D, Abecassis J, Wasylyk B.

Prediction of future metastasis and molecular characterization of head and neck squamous-cell carcinoma based on transcriptome and genome analysis by microarrays

Oncogene. 2008 Nov 20;27(51):6607-22.

Rickman DS, Millon R, De Reynies A, Thomas E, Wasylyk C, Muller D, Abecassis J, Wasylyk B.

PMID: 18679425

EML4-ALK fusion lung cancer: a rare acquired event

March 1, 2008
Perner S, Wagner PL, Demichelis F, Mehra R, Lafargue CJ, Moss BJ, Arbogast S, Soltermann A, Weder W, Giordano TJ, Beer DG, Rickman DS, Chinnaiyan AM, Moch H, Rubin MA.

EML4-ALK fusion lung cancer: a rare acquired event

Neoplasia. 2008 Mar;10(3):298-302.

Perner S, Wagner PL, Demichelis F, Mehra R, Lafargue CJ, Moss BJ, Arbogast S, Soltermann A, Weder W, Giordano TJ, Beer DG, Rickman DS, Chinnaiyan AM, Moch H, Rubin MA.

PMID: 18320074; PMCID: PMC2259458

The gene expression profile of nodal peripheral T-cell lymphoma demonstrates a molecular link between angioimmunoblastic T-cell lymphoma (AITL) and follicular helper T (TFH) cells.

June 1, 2007
de Leval L, Rickman DS, Thielen C, Reynies Ad, Huang YL, Delsol G, Lamant L, Leroy K, Brière J, Molina T, Berger F, Gisselbrecht C, Xerri L, Gaulard P.

The gene expression profile of nodal peripheral T-cell lymphoma demonstrates a molecular link between angioimmunoblastic T-cell lymphoma (AITL) and follicular helper T (TFH) cells.

Blood. 2007 Jun 1;109(11):4952-63.

de Leval L, Rickman DS, Thielen C, Reynies Ad, Huang YL, Delsol G, Lamant L, Leroy K, Brière J, Molina T, Berger F, Gisselbrecht C, Xerri L, Gaulard P.

PMID: 17284527

Pre-TCR expression cooperates with TEL-JAK2 to transform immature thymocytes and induce T-cell leukemia

May 1, 2007
dos Santos NR, Rickman DS, de Reynies A, Cormier F, Williame M, Blanchard C, Stern MH, Ghysdael J.

Pre-TCR expression cooperates with TEL-JAK2 to transform immature thymocytes and induce T-cell leukemia

Blood. 2007 May 1;109(9):3972-81.

dos Santos NR, Rickman DS, de Reynies A, Cormier F, Williame M, Blanchard C, Stern MH, Ghysdael J.

PubMed PMID: 17192390

Gene-expression profiling of systemic anaplastic large-cell lymphoma reveals differences based on ALK status and two distinct morphologic ALK+ subtypes

March 1, 2007
Lamant L, de Reyniès A, Duplantier MM, Rickman DS, Sabourdy F, Giuriato S, Brugières L, Gaulard P, Espinos E, Delsol G.

Gene-expression profiling of systemic anaplastic large-cell lymphoma reveals differences based on ALK status and two distinct morphologic ALK+ subtypes

Blood. 2007 Mar 1;109(5):2156-64.

Lamant L, de Reyniès A, Duplantier MM, Rickman DS, Sabourdy F, Giuriato S, Brugières L, Gaulard P, Espinos E, Delsol G.

PMID: 17077326

Exquisite sensitivity of TP53 mutant and basal breast cancers to a dose-dense epirubicin-cyclophosphamide regimen

March 1, 2007
Bertheau P, Turpin E, Rickman DS, Espié M, de Reyniès A, Feugeas JP, Plassa LF, Soliman H, Varna M, de Roquancourt A, Lehmann-Che J, Beuzard Y, Marty M, Misset JL, Janin A, de Thé H.

Exquisite sensitivity of TP53 mutant and basal breast cancers to a dose-dense epirubicin-cyclophosphamide regimen

PLoS Med. 2007 Mar;4(3):e90.

Bertheau P, Turpin E, Rickman DS, Espié M, de Reyniès A, Feugeas JP, Plassa LF, Soliman H, Varna M, de Roquancourt A, Lehmann-Che J, Beuzard Y, Marty M, Misset JL, Janin A, de Thé H.

PMID: 17388661; PMCID: PMC1831731

Transcriptome classification of HCC is related to gene alterations and to new therapeutic targets

January 1, 2007
Boyault S, Rickman DS, de Reyniès A, Balabaud C, Rebouissou S, Jeannot E, Hérault A, Saric J, Belghiti J, Franco D, Bioulac-Sage P, Laurent-Puig P, Zucman-Rossi J.

Transcriptome classification of HCC is related to gene alterations and to new therapeutic targets

Hepatology. 2007 Jan;45(1):42-52

Boyault S, Rickman DS, de Reyniès A, Balabaud C, Rebouissou S, Jeannot E, Hérault A, Saric J, Belghiti J, Franco D, Bioulac-Sage P, Laurent-Puig P, Zucman-Rossi J.

PubMed PMID: 17187432

Apc tumor suppressor gene is the "zonation-keeper" of mouse liver

June 1, 2006
Benhamouche S, Decaens T, Godard C, Chambrey R, Rickman DS, Moinard C, Vasseur-Cognet M, Kuo CJ, Kahn A, Perret C, Colnot S.

Apc tumor suppressor gene is the "zonation-keeper" of mouse liver

Dev Cell. 2006 Jun;10(6):759-70. 

Benhamouche S, Decaens T, Godard C, Chambrey R, Rickman DS, Moinard C, Vasseur-Cognet M, Kuo CJ, Kahn A, Perret C, Colnot S.

PubMed PMID: 16740478

Distinctive molecular profiles of high-grade and low-grade gliomas based on oligonucleotide microarray analysis

September 15, 2001
Rickman DS, Bobek MP, Misek DE, Kuick R, Blaivas M, Kurnit DM, Taylor J, Hanash SM.

Distinctive molecular profiles of high-grade and low-grade gliomas based on oligonucleotide microarray analysis

Cancer Res. 2001 Sep 15;61(18):6885-91. 

Rickman DS, Bobek MP, Misek DE, Kuick R, Blaivas M, Kurnit DM, Taylor J, Hanash SM.

PubMed PMID: 11559565

The gene for the axonal cell adhesion molecule TAX-1 is amplified and aberrantly expressed in malignant gliomas

March 1, 2001
Rickman DS, Tyagi R, Zhu XX, Bobek MP, Song S, Blaivas M, Misek DE, Israel MA, Kurnit DM, Ross DA, Kish PE, Hanash SM.

The gene for the axonal cell adhesion molecule TAX-1 is amplified and aberrantly expressed in malignant gliomas

Cancer Res. 2001 Mar 1;61(5):2162-8.

Rickman DS, Tyagi R, Zhu XX, Bobek MP, Song S, Blaivas M, Misek DE, Israel MA, Kurnit DM, Ross DA, Kish PE, Hanash SM.

PubMed PMID: 11280781

Research Faculty


General Contact

David Rickman, PhD
Department of Pathology and Laboratory Medicine
Weill Cornell Medical College
1300 York Avenue, Room C-620D
New York, NY 10021
T: 212 -746-9171
F: 212-746-4483
dsr2005@med.cornell.edu

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