Molecular Pathology

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Molecular Pathology

Hanna Rennert, PhD, Principal Investigator

Dr. Rennert's primary research interest is the genetics of autosomal dominant polycystic kidney disease (ADPKD). In collaboration with researchers from The Rogosin Institute and Weill Cornell Medical College in NY we established in 2006 a genetic study for the identification of mutations in PKD1 and PKD2 genes in a cohort of patients with ADPKD, and to correlate this mutations with disease characteristics and patient phenotype.

This patient repository can then serve as a source of information regarding either the entire population, or subsets of patients with specifically targeted characteristics.

Active Projects

  • Autosomal Dominant Polycystic Kidney Disease (ADPKD) Data Repository. This repository was established to characterize and track progression of ADPKD phenotype, and to correlate phenotypes with PKD1 and PKD2 genotypes.
  • Pilot study of genetic changes associated with Autosomal Dominant Polycystic Kidney Disease. This research focuses on the identification of somatic PKD genes mutations in renal epithelial cells derived from patients with ADPKD.

Active Grants

  • Autosomal Dominant Polycystic Kidney Disease (ADPKD) Data Repository
    PI: Blumenfeld
    STARR Foundation

Molecular Pathology

Hanna Rennert, PhD, Principal Investigator

Dr. Rennert's primary research interest is the genetics of autosomal dominant polycystic kidney disease (ADPKD). In collaboration with researchers from The Rogosin Institute and Weill Cornell Medical College in NY we established in 2006 a genetic study for the identification of mutations in PKD1 and PKD2 genes in a cohort of patients with ADPKD, and to correlate this mutations with disease characteristics and patient phenotype.

This patient repository can then serve as a source of information regarding either the entire population, or subsets of patients with specifically targeted characteristics.

Active Projects

  • Autosomal Dominant Polycystic Kidney Disease (ADPKD) Data Repository. This repository was established to characterize and track progression of ADPKD phenotype, and to correlate phenotypes with PKD1 and PKD2 genotypes.
  • Pilot study of genetic changes associated with Autosomal Dominant Polycystic Kidney Disease. This research focuses on the identification of somatic PKD genes mutations in renal epithelial cells derived from patients with ADPKD.

Active Grants

  • Autosomal Dominant Polycystic Kidney Disease (ADPKD) Data Repository
    PI: Blumenfeld
    STARR Foundation

Selected Publications EXPAND ALL ON THIS PAGE

Development and validation of a whole genome amplification long-range PCR sequencing method for ADPKD genotyping of low-level DNA samples.

October 1, 2014
Liu G, Tan AY, Michaeel A, Blumenfeld J, Donahue S, Bobb W, Parker T, Levine D, Rennert H

Development and validation of a whole genome amplification long-range PCR sequencing method for ADPKD genotyping of low-level DNA samples.

Gene. 2014 Oct 15;550(1):131-5.

Liu G, Tan AY, Michaeel A, Blumenfeld J, Donahue S, Bobb W, Parker T, Levine D, Rennert H.

PMID: 25010725

Molecular diagnosis of autosomal dominant polycystic kidney disease using next-generation sequencing.

March 1, 2014
Tan AY, Michaeel A, Liu G, Elemento O, Blumenfeld J, Donahue S, Parker T, Levine D, Rennert H.

Molecular diagnosis of autosomal dominant polycystic kidney disease using next-generation sequencing.

J Mol Diagn. 2014 Mar;16(2):216-28. 

Tan AY, Michaeel A, Liu G, Elemento O, Blumenfeld J, Donahue S, Parker T, Levine D, Rennert H.

PMID: 24374109; PMCID: PMC3937536

Autosomal dominant polycystic kidney disease caused by somatic and germline mosaicism.

March 1, 2014
Tan AY, Blumenfeld J, Michaeel A, Donahue S, Bobb W, Parker T, Levine D, Rennert H.

Autosomal dominant polycystic kidney disease caused by somatic and germline mosaicism.

Clin Genet. 2014 Mar 18. [Epub ahead of print] 

Tan AY, Blumenfeld J, Michaeel A, Donahue S, Bobb W, Parker T, Levine D, Rennert H.

PMID: 24641620.

Urine microRNA as potential biomarkers of autosomal dominant polycystic kidney disease progression: description of miRNA profiles at baseline.

January 1, 2014
Ben-Dov IZ, Tan YC, Morozov P, Wilson PD, Rennert H, Blumenfeld JD, Tuschl T.

Urine microRNA as potential biomarkers of autosomal dominant polycystic kidney disease progression: description of miRNA profiles at baseline.

PLoS One. 2014 Jan 29;9(1):e86856.

Ben-Dov IZ, Tan YC, Morozov P, Wilson PD, Rennert H, Blumenfeld JD, Tuschl T.

PMID: 24489795; PMCID: PMC3906110

Pharmacogenomics and the future of toxicology testing.

September 1, 2012
Agrawal YP, Rennert H.

Pharmacogenomics and the future of toxicology testing.

Clin Lab Med. 2012 Sep;32(3):509-23.

Agrawal YP, Rennert H.

PMID: 22939305

A novel long-range PCR sequencing method for genetic analysis of the entire PKD1 gene.

July 1, 2012
Tan YC, Michaeel A, Blumenfeld J, Donahue S, Parker T, Levine D, Rennert H.

A novel long-range PCR sequencing method for genetic analysis of the entire PKD1 gene.

J Mol Diagn. 2012 Jul;14(4):305-13. 

Tan YC, Michaeel A, Blumenfeld J, Donahue S, Parker T, Levine D, Rennert H.

PMID: 22608885

Evaluation of a BK virus viral load assay using the QIAGEN Artus BK Virus RG PCR test.

July 1, 2012
Rennert H, Jenkins SG, Azurin C, Sipley J.

Evaluation of a BK virus viral load assay using the QIAGEN Artus BK Virus RG PCR test.

J Clin Virol. 2012 Jul;54(3):260-4. 

Rennert H, Jenkins SG, Azurin C, Sipley J.

PMID: 22494899

Development of a novel, and rapid genetic test for autosomal dominant polycystic kidney disease (ADPKD) genes, PKD1 and PKD2 using long-range PCR

January 1, 2012
Tan Y.C., Blumenfeld J., Michaeel A., Donahue S., Parker T., Levine D., and Rennert H

Development of a novel, and rapid genetic test for autosomal dominant polycystic kidney disease (ADPKD) genes, PKD1 and PKD2 using long-range PCR

J Mol. Diag., 14:305-313, 2012.

Tan Y.C., Blumenfeld J., Michaeel A., Donahue S., Parker T., Levine D., and Rennert H

PMID:22608885

Autosomal dominant polycystic kidney disease: genetics, mutations and microRNAs.

October 1, 2011
Tan YC, Blumenfeld J, Rennert H.

Autosomal dominant polycystic kidney disease: genetics, mutations and microRNAs.

Biochim Biophys Acta. 2011 Oct;1812(10):1202-12. 

Tan YC, Blumenfeld J, Rennert H.

PMID: 21392578

Aberrant PKD2 Splicing Due to a Presumed Novel Missense Mutation in Autosomal Dominant Polycystic Kidney Disease

January 1, 2011
Tan Y.C., Blumenfeld J., Michael A., Donahue S., Balina M., Parker T., Levine D. and Rennert H

Aberrant PKD2 Splicing Due to a Presumed Novel Missense Mutation in Autosomal Dominant Polycystic Kidney Disease

Clin. Genet. 80:287-292, 2011.

Tan Y.C., Blumenfeld J., Michael A., Donahue S., Balina M., Parker T., Levine D. and Rennert H

PMID:21392578

Development of a novel, and efficient molecular diagnostic assay for the autosomal dominant polycystic kidney disease (ADPKD) genes, PKD1 and PKD2

January 1, 2009
Tan Y.C., Blumenfeld J., Donahue S., Belenkaya R., Parker T., Levine D., Debra G.B. Leonard and Rennert H

Development of a novel, and efficient molecular diagnostic assay for the autosomal dominant polycystic kidney disease (ADPKD) genes, PKD1 and PKD2

Hum. Mutat., 30(2):264-73, 2009.

Tan Y.C., Blumenfeld J., Donahue S., Belenkaya R., Parker T., Levine D., Debra G.B. Leonard and Rennert H

PMID:22608885

Kidney function and volume progression in unilateral ADPKD with contralateral renal or agenesis hypoplasia: a case series

January 1, 2009
Poster D., Kistler A.D., Krauer F., Blumenfeld J., Renenrt H. Weishaupt D., Wuethrich R.P., and Serra A.L

Kidney function and volume progression in unilateral ADPKD with contralateral renal or agenesis hypoplasia: a case series

Am J Kidney Dis., 54(3):450-8, 2009.

Poster D., Kistler A.D., Krauer F., Blumenfeld J., Renenrt H. Weishaupt D., Wuethrich R.P., and Serra A.L

PMID:19515475

Research Faculty

General Contact

Hanna Rennert, PhD
Associate Professor of Pathology and Laboratory Medicine
Weill Cornell Medical College
1300 York Avenue, C-420
New York, NY 10065
Tel: 212-746-3008
Fax: 212-746-4483
har2006@med.cornell.edu

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