Molecular Gynecologic Pathology

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Molecular Gynecologic Pathology

Lora Hedrick Ellenson, MD, Principal Investigator

Endometrial carcinoma is the most common malignancy of the female genital tract. Although it is often thought of as a single disease, there is epidemiological and clinicopathological evidence to support the view that it encompasses two broad categories of malignant epithelial tumors.

Active Projects

  • Genetic mouse models of endometrial carcinoma
  • Molecular genetic analysis of primary human endometrial carcinomas
  • RNAseq analysis to identify genes regulated by the PI3K/PTEN/AKT pathway

Active Grants

  • Origins of Ovarian Carcinoma
    PI: Lora Hedrick Ellenson, MD
    National Institutes of Health (NIH) Research Subgrant
  • Cancer-prone stem cell niches in ovarian and tubal epithelia
    PI: Lora Hedrick Ellenson, MD
    Ovarian Cancer Research Fund (OCRF) - Research Subgrant
  • Mouse Model of Endometrial Tumorigenesis
    PI: Lora Hedrick Ellenson, MD
    National Cancer Institute (NIH)

Molecular Gynecologic Pathology

Lora Hedrick Ellenson, MD, Principal Investigator

Endometrial carcinoma is the most common malignancy of the female genital tract. Although it is often thought of as a single disease, there is epidemiological and clinicopathological evidence to support the view that it encompasses two broad categories of malignant epithelial tumors.

Active Projects

  • Genetic mouse models of endometrial carcinoma
  • Molecular genetic analysis of primary human endometrial carcinomas
  • RNAseq analysis to identify genes regulated by the PI3K/PTEN/AKT pathway

Active Grants

  • Origins of Ovarian Carcinoma
    PI: Lora Hedrick Ellenson, MD
    National Institutes of Health (NIH) Research Subgrant
  • Cancer-prone stem cell niches in ovarian and tubal epithelia
    PI: Lora Hedrick Ellenson, MD
    Ovarian Cancer Research Fund (OCRF) - Research Subgrant
  • Mouse Model of Endometrial Tumorigenesis
    PI: Lora Hedrick Ellenson, MD
    National Cancer Institute (NIH)

Selected Publications EXPAND ALL ON THIS PAGE

Endometrial tumorigenesis in Pten(+/-) mice is independent of coexistence of estrogen and estrogen receptor α.

June 1, 2012
Joshi A, Wang H, Jiang G, Douglas W, Chan JS, Korach KS, Ellenson LH.

Endometrial tumorigenesis in Pten(+/-) mice is independent of coexistence of estrogen and estrogen receptor α.

Am J Pathol. 2012 Jun;180(6):2536-47. 

Joshi A, Wang H, Jiang G, Douglas W, Chan JS, Korach KS, Ellenson LH.

PMID: 22503752

Adenovirus mediated homozygous endometrial epithelial Pten deletion results in aggressive endometrial carcinoma.

July 1, 2011
Joshi A, Ellenson LH.

Adenovirus mediated homozygous endometrial epithelial Pten deletion results in aggressive endometrial carcinoma.

Exp Cell Res. 2011 Jul 1;317(11):1580-9. 

Joshi A, Ellenson LH.

PMID: 21397598

Molecular Alterations of EGFR and PIK3CA in uterine serous carcinoma

June 1, 2009
Hayes MP, Douglas W and Ellenson LH

Molecular Alterations of EGFR and PIK3CA in uterine serous carcinoma

Gynecol Oncol. 2009 Jun;113(3):370-3. 

Hayes MP, Douglas W, Ellenson LH.

PMID: 19272638; PMCID: PMC2745284

Research faculty

General Contact

Lora H. Ellenson, M.D.
Professor of Pathology and Laboratory Medicine
Weill Cornell Medical College
1300 York Avenue Room F309D
New York, NY 10065
Tel: 212-746-6447
Fax: 212-746-8079
lora.ellenson@med.cornell.edu

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